Argireline Anti-Wrinkle Solution

Argireline (Acetyl Hexapeptide 8) is a peptide compound which is a fragment of SNAP-25, a substrate of botulinum toxin (Botox). It is used in skin care products to reduce the appearance of wrinkles which is caused by repeated facial expressions such as smiling, laughing and frowning. Argireline can temporarily decrease wrinkles by inhibiting the nerves by sending a signal to the muscle, thereby preventing the contraction of muscles.

When Argireline is applied to the skin, it is absorbed into the skin, causing the facial muscles to contract with less force. It can also reduce the appearance of wrinkles and fine lines that appear with aging.

From Journal of Cosmetic and Laser Therapy, 2013,April 22

The anti-wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese subjects
The 60 Chinese subjects received a randomized treatment of argireline or placebo . Argireline or placebo was applied to their periorbital wrinkles twice daily for 4 weeks, and then evaluations were made for the improvements in wrinkles. In the subjective evaluation, Daniell’s classification and Seeman’s standard were applied to make a global assessment of changes in the appearance of periorbital wrinkles. In the objective evaluation, silicone replicas of the skin at the application area were made before and after the treatment, which were analyzed by a wrinkle analysis apparatus.

In the subjective evaluation, the total anti-wrinkle efficacy in the argireline group was 48.9 %, compared with 0 % in the placebo group. In the objective evaluation, the parameters of roughness were all decreased in the argireline group (p< 0.01), while no decrease was obvious in the placebo group (p> 0.05).

This study showed that argireline had a significant anti-wrinkle effect in Chinese subjects.